Police found the ambulance overturned on the curb of US 52 southbound near the Liberty Street exit around 1:16 a.m. Sunday.
Romero was also in the country illegally, the station reported.
Police say 27-year-old Jose Duran Romero's blood-alcohol content was at more than twice the legal limit and he didn't have a driver's license.
Winston-Salem Police reported administering a breathalyzer test to Romero two hours after the crash. Both drivers lost control. The ambulance then rolled over on its side. The others are expected to be OK. The driver of the ambulance and a paramedic also suffered minor injuries from the crash. Police wouldn't tell FOX8 where the passengers in the ambulance were heading or why they were driving through the Triad. He is being held on a $50,000 secured bond, but bail has since been revoked with knowledge of the child's passing. He's charged with DWI, failing to reduce speed to avoid a crash and driving without a license.
Federal authorities lodged an immigration detainer against him after his arrest.
Romero crashed into the side of the ambulance causing it to roll over onto the side of the road
Officials with the Immigration and Customs Enforcement and U.S. Department of Homeland Security use immigration detainers when there are potentially deportable individuals being held in jails and prisons nationwide.
The passenger in the Accord, Andres Figueroa Leon, 33, of the 700 block of Anson Street, was charged with failure to render aid/give information, police said. He has been released from the jail after posting a $1,000 bond, the sheriff's office said.
Newnum didn't have an exact age for the boy or further details on why he was being brought to the area before the crash happened. A witness described what Romero looked like to police after the crash.
Authorities say a young boy is fighting for his life a day after an ambulance carrying him overturned when it was hit by a drunken driver in North Carolina.
Romero is set to make his first appearance in Forsyth District Court Tuesday morning, following by a hearing on April 17.More news: Katie Couric apologizes for Olympic-size gaffe