A charter passenger bus carrying high band school students from Texas crashed Tuesday morning on Interstate 10 at mile marker 57 near the Alabama/Florida line.
An Alabama state trooper confirmed the person killed was the bus driver.
A family member tells KHOU 11 the high schoolers were from Channelview, Texas and on their way back home after a trip to Disney, but Channelview Independent School District has not yet confirmed this information.
Mack said the bus was lying on its side, about 50 feet down the ravine.
Several people were injured and taken to area hospitals, some by air ambulance.
"There's at least one confirmed fatality at this point", Lowery said by telephone.
The sheriff said it wasn't immediately clear what caused the bus to enter the grassy median, which abruptly ends at a steep embankment where the interstate passes over Cowpen Creek, about 25 miles west of Pensacola, Fla., and 30 miles east of Mobile, Ala.More news: Juan Mata states his prediction for Man United v Sevilla
The bus that crashed was one of two carrying students on the trip. He said he did not know how many passengers were injured, but said they were "numerous".
A helicopter has now rushed to the Interstate 10 east of Wilcox Road in the westbound lane to treat any people injured, Fox 23 reported.
The crash shut down I-10 in both directions.
"Everybody is being transferred to a hospital to at least be checked out", he added.
Around 20 patients went to Sacred Heart Hospital in Pensacola, FL, while others were taken to hospitals in Baldwin County, including USA Medical Center in Mobile.
Officials said the Baldwin County Emergency Management Agency facility in Robertsdale, Alabama, would be used as a staging area to reunite non-injured passengers with families. The students were on a trip from Houston, Texas. He also said officials from the National Transportation Safety Board were on their way to the crash scene.
We will be updating this story throughout the morning and day.