Crime Stoppers said the money is for information "that points to criminal activity in the disappearance".
Atlanta police have said no one has heard from 35-year-old Timothy Cunningham since February 12.
A GoFundMe page has brought in more than $24,000 to establish a reward for information that might lead to Dr. Cunningham. The police had earlier said that they haven't found any evidence of foul play.
Cunningham is an epidemiologist at the Atlanta-based federal agency.
Atlanta Police Maj. Michael O'Connor had previously stated in a news conference last month that Cunningham failed to obtain a promotion to branch manager and met with his supervisor to discuss the issue one week before he went missing.
"Over and above any of his assignments at CDC, his early promotion within the USPHS reflects his excellence as an officer and an employee", the statement read.More news: SC: No need link Aadhaar to mobile, bank account until final judgement
If anyone has information about Cunningham, they are asked to call Crime Stoppers Atlanta at 404-577-TIPS (8477).
Despite reports he disappeared right after he was passed over for a promotion, Dr. Schuchat said he'd been given an "early" promotion to the rank of commander, effective July 1 of a year ago, for his "exemplary performance".
Atlanta Police Sgt. John Chafee told CBS News the department stands behind previous statements made regarding Dr. Cunningham's employment, citing the CDC as the direct source of the information.
News reports and investigators have said Dr. Cunningham told co-workers February 12 he wasn't feeling well and had been denied a promotion. O'Connor was sure Cunningham was upset over the lack of promotion because he allegedly shared the news with co-workers.
"He told my husband to tell his wife-me -to erase his cellphone number from my cell phone", Viviana Tory told CBS.