Reacting to the possibility of military action by the United States, Britain, and France, Vassily Nebenzia, Moscow's UN ambassador, said that the current situation was "very risky".
The current escalation of the situation in Syria "has a destructive effect on the whole system of worldwide relations", the Kremlin said.
Western allies, including the United States, the UK, and France, are thought to be preparing for strikes, but Russian Federation, a Syrian ally, has strongly opposed such action.
Following a private meeting of the UN Security Council in New York, Nebenzia also told reporters that, unfortunately, military action by the western allies could not be excluded as a possibility. "They were very bellicose".
Trump himself appeared on Thursday to cast doubt on at least the timing of any US -led military action, tweeting: "Never said when an attack on Syria would take place".
Russia's ambassador to Lebanon on Tuesday had told Lebanon's Al Manar TV that any US missiles fired at Syria would be shot down and the launch sites targeted, Reuters reported.
President Vladimir Putin has said Russian Federation will call an emergency UN Security Council meeting over the air strikes.
What is the West planning?
These developments come as a third resolution in the UN Security Council over the suspected chemical attacks failed to pass.
The United States, France and Britain launched military strikes in Syria to punish regime leader Bashar al Assad for an apparent chemical attack against civilians and to deter him from doing it again, President Donald Trump announced.
Russia, a Syrian ally, has warned the United States that air strikes risk a new war.
But the Violations Documentation Center (VDC), which records alleged violations of global law in Syria, said bodies were found with oral foaming, cyanosis, and corneal burns.More news: Six ministers quit Sri Lanka's troubled government
(A columnist in Kommersant dubbed the whole episode "war by agreement.") In turn, an official close to the Assad regime told Reuters, "We had an early warning of the strike from the Russians". Syrian activists and rescuers say the attack on Douma killed more than 40 people, allegations denied by the government.
"None of the cruise missiles launched by the United States and its allies entered the zones of Russian air defenses around Tartus and Hmeymin", the ministry said in a statement.
Western powers weighed their options on Friday over possible strikes against Syria's regime as pressure built to avoid an escalation and Russian Federation stepped up its warnings against military action which it said could lead to "war".
Saudi Arabia's Crown Prince Muhammad bin Salman, who is now on a visit to France, said that "If our alliance with our partners requires it, we will be present", in reference to the possibility of Saudi Arabia taking part in a joint strike on Syria. "It will just take more lives and spawn the war elsewhere".
Incendiary tweets by President Trump warned "Get ready Russian Federation, because they will be coming, nice and new and 'smart!'"
Russian officials from President Vladimir Putin on down condemned the strike as an act of aggression against a sovereign state carried out on the pretext of staged chemical attack.
Later, a White House briefing on a call between Trump and May said that they "continued their discussion of the need for a joint response to Syria's use of chemical weapons".
"Russia vows to shoot down any and all missiles fired at Syria".
"Never said when an attack on Syria would take place".
USA officials suspect the Russia-backed Assad regime is behind the attack.
In Geneva, U.N. war crimes investigators condemned on Friday the suspected use of chemical weapons in Douma and called for evidence to be preserved with a view to future prosecutions.
In that content, Russian Federation considers states and anti-Assad insurgents as acting in violation of Syria's sovereignty.