Iranian President Hassan Rouhani promptly rejected Pompeo's assertion.
Trump denounced it as "the worst deal ever" for failing to curb Iran's separate ballistic missile programme and its influence in Syria, Yemen, Iraq and Lebanon. The world today doesn't accept that the US decides for the world.
"Today they must show their strength in the face of American pressure", Alaeddin Borujerdi said, according to the Iranian Students' News Agency.
Under a portrait of the late Iranian revolutionary founder Ayatollah Khomeini, worshippers chant slogans in a pro-Palestinian rally in Tehran.
She recalled that the Iran nuclear deal is "the result of more than a decade of complex and delicate negotiations", touting the JCPOA as "the best possible outcome, striking the right balance".
Israeli Prime Minister Benjamin Netanyahu on Tuesday hailed the United States's policy on Iran and urged the rest of the world to follow suit.
But Trump despised the deal, pointing to other aspects of Iranian behaviour not covered in the pact, and on May 8 he pulled America out despite intense diplomatic lobbying by European allies who had beseeched him to stick with it by adding tougher new elements. Behind them lay what Pompeo vowed would be "unprecedented financial pressure" through new sanctions.
"After our sanctions come into full force, it will be battling to keep its economy alive", he added.
It is increasingly clear that Trump's decision to withdraw the United States from the JCPOA and his escalating anti-Iranian rhetoric has given the hardliners in Iran the excuse they needed to discredit Rouhani's moderate government and pave the way for his possible removal from office. "It will not have the resources to do both", Pompeo said. "With friends like that, who needs enemies", European Council President Donald Tusk groused recently. Can it protect its companies which are working in Iran?More news: Person arrested after shots fired at Trump golf club
On Friday, the European Commission launched "the blocking statute" process to protect Europeans from U.S. sanctions on Iran as part of efforts to preserve the nuclear deal with Tehran. "But you know, we will hold those doing prohibited business in Iran to account".
The Trump administration, two weeks after it withdrew from an worldwide arms control deal that curbed Iran's nuclear ambitions, called Monday for a new global coalition to force the Islamic Republic to capitulate to a long list of political and military demands.
"Most European nations are likely to continue their support of the Iran deal because they opposed Trump's ending of that agreement".
The measure was taken after some European companies announced their intention to wind down business in Iran, raising questions about how much the EU can deliver on its promises. "It probably will take a significant amount of time to get a genuine fix for the other Iranian problems", he said. Currently, inspectors must outline the basis for their suspicions.
Yet the U.S. withdrawal from the JCPOA is unlikely to trigger any change in Iran that would be beneficial to Washington. At least six Americans are imprisoned or unaccounted for, and they are widely considered to be bargaining chips. "The global community expects all sides to keep the commitments they made more than two years ago".
"This will only lead to one thing: confrontation", he said.
Pompeo stopped short of calling directly for regime change, but he urged Iranians to think of Rouhani and Foreign Minister Javad Zarif as part of a corrupt, venal and risky regime.
"Iran will never again have carte blanche to dominate the Middle East", Mr Pompeo said. "Yet, Rouhani and Zarif are your elected leaders".
"The regime has been fighting all over the Middle East for years", he said at the Heritage Foundation, a conservative think tank in Washington.