According to the Associated Press, Spade's housekeeping staff found her dead in her NY apartment along with a note.
Law enforcement officials say a housekeeper found the fashion icon dead in her apartment in an apparent suicide Tuesday morning. The officials were not authorized to speak publicly and spoke to The Associated Press on condition of anonymity.
Cole returned to social media hours later and reworked his tribute, writing: "Kate Spade left an indelible mark on the fashion industry and her inspiring life and work will be missed".
In a statement, the company Kate Spade, said: "Although Kate has not been affiliated with the brand for more than a decade, she and her husband and creative partner, Andy, were the founders of our beloved brand".
Born Kate Brosnahan in Kansas City in 1962, she graduated with a degree in journalism from Arizona State University in 1985.
Her spouse is the brother of actor and comedian David Spade, 55, who has appeared in the likes of Saturday Night Live and Grown Ups.More news: 'Beyond disappointed': Serena withdraws from French Open
From the original boxy handbags, she expanded into shoes, luggage and other accessories, as well as a home line, stationery, and three books.
Spade, née Katherine Noel Brosnahan, was famous for her lines of handbags and womenswear, which she founded in 1993 with her husband, Andy. "RIP Kate Spade. Love to her family", tweeted Josh Groban.
In addition to her husband of 22 years, she is survived by a daughter, 13-year-old Frances Beatrix Spade. "I love this pic of her". In 1996, the Kate Spade brand opened its first boutique in SoHo before moving its headquarters to West 25th Street.
"She was a great talent who had an immeasurable impact on American fashion and the way the world viewed American accessories", the statement read.
In an eerie coincidence, Spade was the answer to a "Jeopardy!" question on the night before her death in a "Designer Initials" category: "She made a name for herself in the 1990s with her handbags: K.S".
If you or someone you know needs help, please call the National Suicide Prevention Lifeline at 1-800-273-TALK (8255).