Mahrez has now failed to score five of his last eight Premier League penalties, while Jesus has missed two of his last three for City.
Click on the video above to enjoy the best of the action... In the end, however, the teams finished just as they started, playing to a 0-0 draw to split the points. The logic was similar to that which lay behind the use of Ilkay Gundogan in a right-sided role in the Champions League quarter-final first leg last season, but this time it achieved the desired result, protecting the full-backs and giving City an element of control.
Yet during the closing stages of Manchester City's goalless draw with Liverpool and subsequent post-match debrief, it became clear that one stone had in fact been left unturned by the tactical genius - Riyad Mahrez's record from the penalty spot.
"We played City now very often and they are just outstanding". They have been on a great run.More news: Nike 'deeply concerned' by 'disturbing' rape allegations made against Cristiano Ronaldo
"So there is a long way to go and there will be a lot of teams competing but we hope we are one of them".
The top-of-the-table clash failed to live up to its billing with both sides, the top two Premier League scorers last season, nearly reluctant to commit to full attacking mode for fear of what the other team might do to them if they opened up too much.
"It is not smart to dive in there", Van Dijk told Sky Sports.
"It was a tough game against the champions and I'm happy that we kept the clean sheet, especially after the penalty".
"Today they've done particularly well [against Southampton] but in a game you'd think they would do well".
"But with that fixture list I'd have said "I'll buy it, let's start on the ninth matchday".