But it remains to be seen whether Democrats' rage will amount to the so-called "blue wave" they've anticipated for almost two years, or whether it's even enough to gain the 23 seats needed to eke out a Democratic majority in the House. Early results showed Democrats winning pick-ups in congressional districts in Virginia, Florida, Pennsylvania, Colorado and New Jersey, as voters there sent a message of repudiation against Trump.
That was a risky strategy with a potentially huge reward: had Republicans held on to both chambers of Congress, Trump would have been able to tout another major upset victory.
And Rep. Adam Schiff, slated to become chairman of the House Intelligence Committee, has vowed to probe alleged Trump campaign-Russia collusion.
"Tremendous success tonight. Thank you to all!" he tweeted.
In the last two decades there have only three election cycles where one party picked up 24 or more seats.
Despite capturing the House, Democrats were unable to takeover the Senate, where Republicans maintained a firm majority.
Alongside all 435 House seats and a third of the Senate on the ballot on Tuesday were 36 gubernatorial races.
The GOP also got major wins in toss-up governors races in states like Florida and OH, though Democrats did manage to pick up wins in a number of states like IL and MI.
Republicans expanded their Senate majority while losing control of the House of Representatives Tuesday, limiting President Donald Trump's options for pursuing a pro-life agenda for the remainder of his first term.
Republicans paved their path to victory by defeating Democrats Joe Donnelly of Indiana, Heidi Heitkamp of North Dakota and Claire McCaskill of Missouri.More news: Warriors coach Steve Kerr says Zion Williamson could be next LeBron James
The Democratic gains could have big effects, soon and longer term.
Former vice president Joe Biden, often touted as a possible Democratic candidate to take on Trump in 2020, said he'd have been "dumbfounded" not to win the House.
It could have been a much bigger night for Democrats, who suffered stinging losses in OH and in Florida, where Trump-backed Republican Ron DeSantis ended Democrat Andrew Gillum's bid to become the state's first African-American governor.
Senators Bernie Sanders of Vermont, a 2016 Democratic presidential contender, and Tim Kaine of Virginia, Hillary Clinton's vice presidential nominee in 2016, easily won re-election.
With slim margins of control and differences between progressives and more moderate members, Democrats put off more ambitious legislation. Democrats also captured governorships in MI and IL.
His visits included overt reminders to his base supporters that they weren't just voting for any Republican on the ballot - they were voting for senators promising to back his priorities.
That would give the Senate the role of blocking House-passed Democratic initiatives on everything from health care to the potential repeal of tax cuts on the wealthy that the GOP enacted past year. Trump was badly underwater among women voters - who favor Democrats 62% to 35% - a gender gap, that if borne out by real votes, could prove devastating to Republican hopes.
Democratic control of the House would break the GOP's monopoly on power in Washington and would nearly certainly lead to an onslaught of investigations of Trump's businesses and his administration. Such a development would divide control of the USA legislature and hinder President Donald Trump's policy agenda for the next two years.
The loss of power will test Trump's political hold on House Republicans, most of whom had pledged their support for him lest they face the wrath of the party's core supporters, who remain in his corner.
With divided leadership in Congress and a president who has taken an expansive view of executive power, Washington could be in store for even deeper political polarisation and legislative gridlock.
"It's a consequential election", Yorgo Koutsogiogasi, a 64-year-old immigrant from Greece and CEO of a hospitality company, said as he voted in Chicago.